Blade (Snipes) is back on his quest to rid the world of vampires. When the original vampire, Danica Talos (Purcell) returns, Blake is going to find his job a lot harder. Especially, when the public believe Blade is the real villain. He teams up with the daughter of Whistler, Abigail (Biel) and a former vampire, Hannibal King (Reynolds) to attempt a plan, which could destroy every vampire in existence.

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