Van Helsing (Jackman) is in the world to rid all evil, even if not everyone agrees with him. The Vatican send the monster hunter and his ally, Carl (Wenham) to Transylvania. They have been sent to this land to stop the powerful Count Dracula (Roxburgh). Whilst, here they join forces with a Gypsy Princess called Anna Valerious (Beckinsale), who is determined to end an ancient curse on her family, by destroying the vampire. They just don't know how!